Restylane® Refyne

• Restylane Refyne temporarily reduces signs of aging on your face by smoothing the wrinkles and folds that form around your nose and extending down to the corners of your mouth (laugh lines). This natural, smooth look should last for up to 12 months.
• Restylane Refyne was studied in many patients like yourself to determine if it was effective in treating laugh lines and to ensure that it is safe for use.

The study doctors reported:
• 79% of patients had at least a 1-point improvement in wrinkle appearance 6 months after treatment
• 62% of patients had at least a 1-point improvement in wrinkle appearance 1 year after treatment

The patients reported:
• 79% rated an improvement in the appearance of their wrinkles 6 months after treatment
• 67% rated an improvement in the appearance of their wrinkles 1 year after treatment

What is Restylane Refyne?
Restylane Refyne is a dermal filler injected under the (facial) skin. Once in place, it helps smooth away your “laugh lines” – the wrinkles and folds that may form at the sides of your nose and run down toward the corners of your mouth.

Restylane Refyne is made out of hyaluronic acid - a naturally occurring sugar, found in the body that gives the skin moisture, volume, and elasticity – and a small amount of lidocaine, which is a commonly used local anesthetic to numb the skin.

Restylane Refyne is made using a manufacturing process called XpresHAn Technology™, which creates a smooth, injectable gel that can give your skin a natural, soft look

What is Restylane Refyne for?
As you age, your facial skin begins to lose its elasticity and volume. As a result, your “laugh lines”, the creases that run from the sides of your nose toward the corners of your mouth, become more pronounced. Restylane Refyne injectable gel is designed to temporarily help counter this by smoothing out these wrinkles and folds and restoring a natural, soft look to your face. Restylane Refyne has been shown to maintain this effect for up to 12 months.

Are there any reasons why I should not receive Restylane Refyne?
Before using Restylane Refyne, your doctor will talk to you about your medical history to determine if you are an appropriate candidate for treatment. You will be asked questions about possible allergies to ensure that Restylane Refyne can be safely administered. Tell your doctor about all of your medical conditions, including if you:
• Have severe allergies with a history of severe reactions (anaphylaxis). Use of Restylane Refyne may result in an allergic reaction.
• Are allergic to the anesthetic lidocaine or to any of the proteins used to make the hyaluronic acid in Restylane Refyne (bacterial proteins). Use may result in an allergic reaction.

What side effects were seen in the clinical study?
In the study of Restylane Refyne, most patients reported the following side effects at the site where they received the injection:
• Swelling
• Bruising
• Lumps/Bump Formation
• Pain/Tenderness
• Itching
• Redness
Most patients said their side effects were mild, short-lived, and did not require them to call their doctor. These patients said that their side effects disappeared within 1-2 weeks.
Patients also reported that the anesthetic lidocaine, which is part of the Restylane Refyne injection and used to numb the injection site, significantly reduced pain during and after their procedure.